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ORIGINAL ARTICLE
Year : 2016  |  Volume : 35  |  Issue : 2  |  Page : 122-131

Clinicopathological features and surgical outcomes of esophagogastric junction adenocarcinoma single center experience: a retrospective cohort study


Gastroenterology Surgical Center, Mansoura University, Mansoura, Egypt

Correspondence Address:
Ayman El Nakeeb
MD, Gastroenterology Surgical Center, Mansoura University, Mansoura 35516
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-1121.182787

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Background The esophagogastric cancers (EGCs) are rapidly increasing in Western countries. This study was conducted to elucidate the distribution and surgical outcomes of EGC. Patients and methods We retrospectively studied 90 patients who underwent curative surgery for esophagogastric junction cancer according to Siewert's classification during the period between January 2005 and July 2014. The collected information included preoperative, operative, and postoperative data. We also compared these data among the EGC subtypes. Results A total of 90 patients were eligible and were included in the study. The median follow-up period was 17.68 (0.2-130.92) months. Thirty-five patients had type I (38.9%), 32 had type II (35.6%), and 23 patients had type III tumors (25.6%). There were no significant differences in age, sex, and Borrmann macroscopic types between the three subtypes. Thoracotomy was used most often in type I tumors (74.3%) as compared with type II (28.1%) and type III (13%) tumors (P = 0.0001). Multivariate analysis confirmed that only tumor size (P = 0.023) and lymph node metastasis (P = 0.020) and presence of Borrmann macroscopic appearance of type II tumor (0.039) were significant and independent prognostic indicators for survival after curative resection for EGC. Conclusion The selection of the surgical approach for resection of EGC carcinoma should be tailored and achieving tumor-free safety margin. Tumor size and lymph node metastasis and presence of Borrmann macroscopic appearance of type II tumor were significant and independent prognostic indicators for survival after curative resection for EGC.


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